A portion of amino acids 500-526 from the human protein was used as the immunogen for this ASIC1 antibody.
ACCN2 / ASIC1 is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member is expressed in most if not all brain neurons, and it may be an ion channel subunit, however, its function as an ion channel remains unknown.
