SP1 Antibody / Specificity Protein 1, Clone: [1326CT463.109.176], Mouse, Monoclonal
Biozol Catalog Number:
NSJ-F52486-0.4ML
Supplier Catalog Number:
F52486-0.4ML
Alternative Catalog Number:
NSJ-F52486-0.4ML
Manufacturer:
NSJ Bioreagents
Host:
Mouse
Category:
Antikörper
Application:
ELISA, FACS, IF, WB
Species Reactivity:
Human
Immunogen:
This SP1 antibody was produced from a mouse immunized with recombinant Specificity Protein 1.
Specificity Protein 1/SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. [UniProt]
