A portion of amino acids 89-118 from the human protein was used as the immunogen for the NUDT15 antibody.
Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.
The stated application concentrations are suggested starting points. Titration of the NUDT15 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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