A portion of amino acids 239-267 from the human protein was used as the immunogen for the CD82 antibody.
The ST6 metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients.
The stated application concentrations are suggested starting points. Titration of the CD82 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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