Amino acids 24-97 of human Eotaxin/CCL11 were used as the immunogen for the CCL11 antibody.
CCL11 (Chemokine (C-C motif) ligand 11), also known as Eotaxin, is a small cytokine belonging to the CC chemokine family. Eotaxin selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of Eotaxin are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which Eotaxin is a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3. The gene for human Eotaxin is encoded on three exons and is located on chromosome 17q12.
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Purity:
Antigen affinity
Form:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Antibody Type:
Primary Antibody
Application Dilute:
Western blot: 0.5-1ug/ml (recombinant protein),Immunohistochemistry (FFPE): 2-5ug/ml,ELISA: 0.1-0.5ug/ml (human protein tested), request BSA-free format for coating
Application Notes:
Optimal dilution of the CCL11 antibody should be determined by the researcher.
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