Calcineurin A Antibody / PPP3CA, Rabbit, Polyclonal
Biozol Catalog Number:
NSJ-R32200
Supplier Catalog Number:
R32200
Alternative Catalog Number:
NSJ-R32200
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
WB
Species Reactivity:
Human
Immunogen:
Amino acids DAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ of human Calcineurin A were used as the immunogen for the Calcineurin A antibody.
Calcineurin A is also known as PPP3CA. It is mapped to 4q24. Semsarian et al. (1999) and Musaro et al. (1999) independently showed that IGF1stimulates skeletal muscle hypertrophy and a switch to glycolytic metabolism by activating calcineurin A and inducing the nuclear translocation of transcription factor NFATC1. Semsarian et al. (1999) found that hypertrophy was suppressed by the calcineurin inhibitors cyclosporin A or FK506, but not by inhibitors of the MAP kinase or phosphatidylinositol-3-OH kinase pathways. Musaro et al. (1999) showed that expression of a dominant-negative calcineurin mutant also repressed myocyte differentiation and hypertrophy. Musaro et al. (1999) demonstrated that either IGF1 or activated calcineurin induces expression of transcription factor GATA2, which accumulates in a subset of myocyte nuclei, where it associates with calcineurin and a specific dephosphorylated isoform of NFATC1.
