HLA-E Antibody / MHC class I antigen E, Clone: [HLAE/9468], Mouse, Monoclonal
Biozol Catalog Number:
NSJ-V5733-20UG
Supplier Catalog Number:
V5733-20UG
Alternative Catalog Number:
NSJ-V5733-20UG
Manufacturer:
NSJ Bioreagents
Host:
Mouse
Category:
Antikörper
Application:
IHC-P
Species Reactivity:
Human
Immunogen:
A portion of amino acids 1-150 from human HLAE protein was used as the immunogen for the HLA-E antibody.
Major histocompatibility complex (MHC) molecules, which include human leukocyte antigens (HLAs), form an integral part of the immune response system. They are cell-surface receptors that bind foreign peptides and present them to cytotoxic T lymphocytes (CTLs). MHC class I molecules consist of two polypeptide chains, an a or heavy chain and a non-covalently associated protein, b-2-Microglobulin. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-A is a MHC class I heavy chain molecule that plays a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and HLA-C are proteins encoded by closely related genes that also exist in the MHC class I. HLA-E belongs to the HLA class I heavy chain paralogs. HLA-E is a heterodimer consisting of a heavy chain and a light chain. The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules.
