Calcineurin B Antibody / PPP3R1, Clone: [BE2.1], Mouse, Monoclonal
Biozol Catalog Number:
NSJ-V8029SAF-100UG
Supplier Catalog Number:
V8029SAF-100UG
Alternative Catalog Number:
NSJ-V8029SAF-100UG
Manufacturer:
NSJ Bioreagents
Host:
Mouse
Category:
Antikörper
Application:
IHC-P, WB
Species Reactivity:
Human
Immunogen:
A recombinant full-length human Calcineurin B protein was used as the immunogen for the Calcineurin B antibody.
Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59kDa catalytic A subunit and a 19kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
