Clostridium difficile Toxin A Antibody, Clone: [253/422], Mouse, Monoclonal
Biozol Catalog Number:
NSJ-V8285-100UG
Supplier Catalog Number:
V8285-100UG
Alternative Catalog Number:
NSJ-V8285-100UG
Manufacturer:
NSJ Bioreagents
Host:
Mouse
Category:
Antikörper
Application:
ELISA, IF
Species Reactivity:
Bacteria
Immunogen:
C. difficile Toxin A was used as the immunogen for the Clostridium difficile Toxin A antibody.
This mAb reacts with C. difficile Toxin A, but not with Cholera subunit a, Cholera toxin, Pseudomonas aeruginosa exotoxin A, H-LT, P-LT. Clostridium difficile is a major nosocomial pathogen that causes antibiotic- associated colitis. Clostridium difficile mediates inflammatory diarrhea by releasing two large protein enterotoxins (Toxin A and Toxin B) that are able to disrupt intestinal epithelial cells via their transferase activity and ability to monoglucosylate members of the Rho family. Clostridium difficile Toxin A is a toxin that is composed of 39 repeats that are responsible for binding to intestinal epithelial cell surface carbohydrates. Clostridium difficile Toxin A causes significant apoptosis of colonocytes which contributes to the formation of ulcers and pseudo-membranes in a pathway that involves p38-dependent activation of p53 and induction of p21, leading to cytochrome c release and caspase-3 activation through Bak activation.
