Recombinant full-length human CD268 protein was used as the immunogen for the BAFF-R antibody.
Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4), also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins, the numbers of circulating B cells is usually in the normal range, but can be low.
