WM3311 is a human metastatic melanoma cell line. This cell line was established from a metastatic site from a patient. These cells are known to have mutations in GRIN2A, PRDM1, TERT, and are upregulated in Notch2. These cells are different from many melanoma cell lines in that they lack the common V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This cell line is wild type for BRAF, N-RAS, c-KIT, and CDK4. WM3311 cells produce xenograft tumors when injected into immunocompromised mice.
Concentration:
1.0 million cells/mL (Count By Hemocytometer)
Buffer:
None
Source:
Human
Form:
Frozen Cell Suspension
Application Notes:
The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways.
Human melanoma tumor cells with known gene mutations, disease stage, STR, and RPPA profiling
Established WM3311 viable cell growth in culture using appropriate Tumor Specialized Media with 2%FBS.
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