WM3622 is a metastatic human melanoma cell line that display large flat cell morphology. This cell line contains a F337S mutation in the PTEN gene. The codon for phe337 is replaced with a serine residue and this substitution could be highly detrimental to catalysis by PTEN and to its conformational stability. WM3622 cells produce xenograft tumors when injected into immunocompromised mice.
Concentration:
1.0 million cells/mL (Count By Hemocytometer)
Buffer:
None
Source:
Human
Form:
Frozen Cell Suspension
Application Notes:
The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways.
Human melanoma tumor cells with known gene mutations, disease stage, STR, and RPPA profiling
Established WM3622 viable cell growth in culture using appropriate Tumor Specialized Media with 2%FBS.
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