WM3772F is a primary human metastatic uveal melanoma cell line displaying clumpy pigmented morphology. These cells require 5% FBS to adhere to culture flask. This cell line was established from a metastases arising from uveal melanoma of a patient. Uveal melanoma is a rare type of cancer of an eye and can arise in the anterior (iris) or the posterior (ciliary body or choroid) uveal tract. Most uveal tract melanomas originate in the choroid. The ciliary body is less commonly a site of origin, and the iris is the least common. This cell line expresses wild type BRAF, N-RAS, c-KIT, and CDK4 genes. WM3772F cells match with WM3618F. These cells produce xenograft tumors when injected into immunocompromised mice.
Concentration:
1.0 million cells/mL (Count By Hemocytometer)
Buffer:
None
Source:
Human
Form:
Frozen Cell Suspension
Application Notes:
The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways.
Human melanoma tumor cells with known gene mutations, disease stage, STR, and RPPA profiling
Established WM3772F viable cell growth in culture using appropriate Tumor Specialized Media with 5%FBS.
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