RECQL5-IN-1 is an orally active RECQL5 inhibitor (IC50 = 46.3 nM) that simultaneously targets both enzymatic and non-enzymatic domains. RECQL5-IN-1 stabilizes the interaction between RECQL5 and RAD51 proteins, disrupting homologous recombination repair (HRR), thereby selectively killing cancer cells that express RECQL5.
Molecular Weight:
552.49
CAS Number:
[2718170-45-5]
Formula:
C25H18F6N4O2S
Target:
DNA/RNA Synthesis
T63899
T63899
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