TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM). It induces folate trapping and cell cycle arrest, thereby selectively killing cancer cells expressing MTHFD2.
Molecular Weight:
451.37
Purity:
98.07%
CAS Number:
[2379556-22-4]
Formula:
C17H18FN7O7
Target:
Cell Cycle Arrest|||Antifolate|||DHFR
T87512
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