D3S-001 is an orally effective KRAS inhibitor. It suppresses the proliferation of the KRASG12C mutants H358 and MIA-PA-CA-2 with IC50 values of 0.6 and 0.44 nM, respectively. D3S-001 exhibits good metabolic stability across multiple species in hepatocytes, liver microsomes, plasma, and whole blood. Additionally, it demonstrates favorable pharmacokinetic properties and antitumor activity in mice.
Molecular Weight:
679.66
CAS Number:
[2914919-85-8]
Formula:
C32H35F6N7O3
Target:
Ras|||Kras
T89626
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