AES-350 is a potent and orally active HDAC6 inhibitor (IC50 and Ki of 0.0244 µM and 0.035 µM, respectively), also exhibiting activity against HDAC-3, -8, and -11 in an enzymatic assay with IC50 values of 0.187 µM, 0.245 µM, and >1 µM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.
Molecular Weight:
312.36
Purity:
98.82%
CAS Number:
[847249-57-4]
Formula:
C18H20N2O3
Target:
HDAC|||Apoptosis
T9041
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