Anti-ACVR2B Antibody is a highly specific monoclonal antibody targeting the human activin receptor type IIB (ACVR2B). The compound binds to the extracellular domain of ACVR2B to effectively block signaling mediated by ligands such as activin and myostatin, thereby inhibiting downstream Smad2/3 phosphorylation. In experimental research, it serves as a critical tool for modulating muscle mass and metabolic homeostasis to investigate muscle atrophy, osteoporosis, and cancer-associated cachexia.
Target:
TGF-beta/Smad
T9901A-1340
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