Coelonin is a dihydrophenanthrene compound with anti-inflammatory activity. Coelonin can inhibit the phosphorylation of PTEN induced by LPS, and inhibit the activation of NF-kappaB and the degradation of p27 Kip1 by negatively regulating PI3K/AKT signaling pathway. Coelonin can also inhibit the phosphorylation and degradation of IkappaBalpha, thus up-regulating the level of IkappaBalpha protein.
Molecular Weight:
242.27
CAS Number:
[82344-82-9]
Formula:
C15H14O3
Target:
NF-kappaB|||Akt|||IL Receptor
TN3688
TN3688
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