A nonsteroidal estrogen antagonist. Benzoestrol is a synthetic estrogenic compound that is used in the treatment of breast cancer. Benzoestrol binds to estrogen receptors and has been shown to inhibit the growth of aerobacter aerogenes. It also has been reported that benzoestrol demonstrated antiproliferative effects on human breast cancer cells, which were mediated by an estrogen receptor-dependent mechanism. The toxicity studies of benzoestrol have revealed that it does not produce mutations in the DNA or chromosomal aberrations. Benzoestrol has shown no genotoxic effects in vivo or in vitro at doses up to 10uM. Synonyms: 4,4-(1,2-Diethyl-3-methyl-1,3-propanediyl)bisphenol, 3-Ethyl-2,4-bis(p-hydroxyphenyl)hexane, Chemestrogen, NSC 408889, Octestrol, Octoestrol, Octofollin, Oktestrol CAS No: 85-95-0 Molecular Formula: C20H26O2 Molecular Weight: 298.42 Appearance: White to off-white solid Purity: 97% (HPLC) NMR, MS: Conforms to reference Specific Rotation: -0.5 (c = 0.2, Methanol) Melting Point: 161-163C Elemental Analysis: %C: 80.46, %H: 8.99 Solubility: Ethyl Acetate (Slightly), Methanol (Slightly) Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight:
298.42
Purity:
97% (HPLC)
Form:
White to off-white solid
CAS Number:
[85-95-0]
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