CD166 (ALCAM, Activated Leukocyte Cell Adhesion Molecule) (Biotin), Goat
Catalog Number:
USB-C2548-90M8
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| Article Name: | CD166 (ALCAM, Activated Leukocyte Cell Adhesion Molecule) (Biotin), Goat |
| Biozol Catalog Number: | USB-C2548-90M8 |
| Supplier Catalog Number: | C2548-90M8 |
| Alternative Catalog Number: | USB-C2548-90M8-50 |
| Manufacturer: | US Biological |
| Host: | Goat |
| Category: | Antikörper |
| Application: | ELISA, WB |
| Immunogen: | Recombinant protein corresponding to Trp28-Ala526 from human ALCAM, expressed in NS0 cells. |
| ALCAM, activated leukocyte cell adhesion molecule, is a type I membrane glycoprotein and a member of the immunoglobulin supergene family. It is also known as CD166, MEMD, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat. ALCAM is expressed on thymic epithelial cells, activated B and T cells, and monocytes. ALCAM can bind itself homotypically and is also capable of binding CD6, NgCAM, and other, as of yet, unidentified brain proteins. The ALCAM/CD6 interaction may be involved in T cell development and T cell regulation. Additionally, ALCAM/CD6 and ALCAM/NgCAM interactions may play roles in the nervous system. ALCAM has also been observed to be up-regulated on highly metastasizing melanoma cell lines and may play a role in tumor migration. ALCAM is a 583 amino acid (aa) protein consisting of a 27 aa signal peptide, a 500 aa extracellular domain, a 24 aa transmembrane domain and a 32 aa cytoplasmic domain. The extracellular domain of ALCAM contains 5 Ig-like domains. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 0.1ug/ml ELISA (detection): 0.1-0.4ug/ml in combination with the monoclonal capture antibody (Catalog C2548-90P). Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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