EAAT3 (4R8) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE10265
Produktübersicht
Artikelname:
EAAT3 (4R8) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE10265
Hersteller Artikelnummer:
AMRe10265
Alternativnummer:
EKL-AMRE10265-50UL, EKL-AMRE10265-100UL, EKL-AMRE10265-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC, WB
Spezies Reaktivität:
Human
Konjugation:
Unconjugated
Alternative Synonym:
SLC1A1, EAAC1, EAAT3, Eaac-1,
Produktbeschreibung
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed: 7521911, PubMed: 8857541, PubMed: 26690923, PubMed: 21123949). Can also transport L-cysteine (PubMed: 21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed: 7521911, PubMed: 8857541, PubMed: 26690923). Mediates Cl(-) flux that is not coupled to amino acid transport, this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed: 8857541, PubMed: 26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed: 21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
57kDa
NCBI:
6505
UniProt:
P43005
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
SLC1A1
Anwendungsbeschreibung
Application Verdünnung:
WB 1:2000-1:20000,IHC 1:200-1:1000
