EAAT3 (4R8) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE10265
Product Overview
Article Name:
EAAT3 (4R8) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE10265
Supplier Catalog Number:
AMRe10265
Alternative Catalog Number:
EKL-AMRE10265-50UL, EKL-AMRE10265-100UL, EKL-AMRE10265-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
IHC, WB
Species Reactivity:
Human
Conjugation:
Unconjugated
Alternative Names:
SLC1A1, EAAC1, EAAT3, Eaac-1,
Product Description
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed: 7521911, PubMed: 8857541, PubMed: 26690923, PubMed: 21123949). Can also transport L-cysteine (PubMed: 21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed: 7521911, PubMed: 8857541, PubMed: 26690923). Mediates Cl(-) flux that is not coupled to amino acid transport, this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed: 8857541, PubMed: 26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed: 21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity).
Product Properties
Clonality:
Monoclonal
Molecular Weight:
57kDa
NCBI:
6505
UniProt:
P43005
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
SLC1A1
Application Notes
Application Dilute:
WB 1:2000-1:20000,IHC 1:200-1:1000
