PDX1 Antibody / Pancreas/duodenum homeobox protein 1, Rabbit, Polyclonal
Artikelnummer:
NSJ-F50728-0.08ML
Hersteller Artikelnummer:
F50728-0.08ML
Alternativnummer:
NSJ-F50728-0.08ML
Hersteller:
NSJ Bioreagents
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
ELISA, IHC, WB
Spezies Reaktivität:
Human
Immunogen:
A portion of amino acids 40-69 from the human protein was used as the immunogen for this PDX1 antibody.
PDX1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. This nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in the gene encoding PDX1 are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
