PDX1 Antibody / Pancreas/duodenum homeobox protein 1, Rabbit, Polyclonal
Biozol Catalog Number:
NSJ-F50728-0.08ML
Supplier Catalog Number:
F50728-0.08ML
Alternative Catalog Number:
NSJ-F50728-0.08ML
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
ELISA, IHC, WB
Species Reactivity:
Human
Immunogen:
A portion of amino acids 40-69 from the human protein was used as the immunogen for this PDX1 antibody.
PDX1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. This nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in the gene encoding PDX1 are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
