DK419 is a potent, orally bioavailable small molecule inhibitor of the Wnt/beta-catenin pathway (IC50 = 0.19 µM). It downregulates key oncogenic targets including Axin2, beta-catenin, c-Myc, Cyclin D1, and Survivin while activating pAMPK. This inhibitor is a valuable research tool for studying Wnt-driven cancers in both cellular and animal models.
Molecular Weight:
407.7
Purity:
99.63% (May vary between batches)
CAS Number:
[2102672-22-8]
Formula:
C16H8ClF6N3O
Target:
CDK,c-Myc,AMPK,Survivin,Wnt/beta-catenin
Application Notes:
Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)
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