Anti-TSLP Reference Antibody is expressed from CHO. The heavy chain type is huIgG2, and the light chain type is hulambda. It has a predicted MW of 145.5 kDa.
Anti-TSLP Reference Antibody (tezepelumab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.
The purity of Anti-TSLP Reference Antibody (tezepelumab)is more than 98.64% ,determined by SEC-HPLC.
Immobilized human TSLP His at 2 µg/mL can bind Anti-TSLP Reference Antibody (tezepelumab),EC50=0.0518µg/mL.
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Anti-TSLP Reference Antibody (tezepelumab)-induced FACS Blocking activity was evaluated using TSLPR/IL7R-CHO-K. The IC50 was approximately 0.0802 µg/mL.
Tezepelumab reduced levels of IL13 in BALF of OVA asthma model on B-hTSLP/hTSLPR mice. The result showed significant IL13 inhibition effects at 15 mpk.
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