Amyloid beta Precusor Protein Antibody, Rabbit, Polyclonal
Biozol Catalog Number:
NSJ-F51499-0.4ML
Supplier Catalog Number:
F51499-0.4ML
Alternative Catalog Number:
NSJ-F51499-0.4ML
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
ELISA, WB
Species Reactivity:
Human
Immunogen:
A portion of amino acids 735-763 from the human protein was used as the immunogen for this Amyloid beta precusor protein antibody.
APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
